Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek.
When sexual stimulation causes neighborhood launch of NO, inhibition of PDE5 by sildenafil results in elevated levels of cGMP while in the corpus cavernosum, leading to smooth muscle mass leisure and inflow of blood for the corpus cavernosum. Sildenafil at recommended doses has no outcome within the absence of sexual stimulation.
This metabolite provides a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 close to 50% of your mum or dad drug. Plasma concentrations of the metabolite are approximately forty% of People seen for sildenafil, so that the metabolite accounts for around twenty% of sildenafil's pharmacologic consequences.
As a result, the metabolite is chargeable for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly from the feces (about 80% of administered oral dose) and also to a lesser extent in the urine (all around 13% with the administered oral dose). If taken which has a substantial-Excess fat food, absorption is diminished; enough time taken to achieve the most plasma focus will increase by about one hour, and the utmost concentration by itself is lowered by nearly just one-3rd.[fifty two]
Administration of VIAGRA with nitric oxide donors such as organic and natural nitrates or natural and organic nitrites in any sort is contraindicated.
In Those people clients now having an optimized dose of the PDE5 inhibitor, alpha-blocker therapy really should be initiated at the lowest dose. Stepwise rise in alpha-blocker dose could possibly be associated with more decreasing of hypertension when taking a PDE5 inhibitor.
There are postmarketing reviews of bleeding gatherings in clients who have taken VIAGRA. A causal marriage between VIAGRA and these activities has not been proven. In people, VIAGRA has no impact on bleeding time when taken by itself or with aspirin.
This Assessment was performed retrospectively, and wasn't powered to detect any pre-specified variation in adverse reactions.
These mixtures may well even more lower blood pressure level. As a result, the use of these combos will not be suggested.
Snakk med lege fileør du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakning og pakningsvedlegg nøye før bruk.
VIAGRA can cause your blood pressure level to fall instantly to an unsafe degree if it is taken with sure other medicines. Tend not to choose VIAGRA if you are taking almost every other medicines termed “nitrates.
50 mg er den mest foreskrevne dosen og den beste startdosen for de fleste fileørstegangsbrukere. Det betyr at dosen er lett å justere hvis den ikke fungerer for deg eller du opplever bivirkninger.
Blood pressure was measured following administration of VIAGRA at exactly the same situations as People specified with more info the preceding doxazosin experiments. There have been a few subjects who had a standing SBP of < eighty five mmHg. All 3 have been having VIAGRA 100 mg, and all a few documented delicate adverse activities at time of reductions in standing SBP, including vasodilation and lightheadedness. There were four topics by using a minimize from baseline in standing systolic BP > thirty mmHg adhering to VIAGRA one hundred mg, just one issue with a decrease from baseline in standing systolic BP > 30 mmHg next placebo and one subject with a lessen from baseline in standing systolic BP > 30 mmHg next equally VIAGRA and placebo.
It is actually not possible to ascertain whether or not these occasions are relevant straight to the use of PDE5 inhibitors, on the patient's underlying vascular possibility variables or anatomical defects, to a combination of these aspects, or to other elements [see WARNINGS AND PRECAUTIONS and Affected person Information and facts].